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Between 1990 and 2011, prototype products were constructed and tested to understand the aerosol chemistry involved, measure the levels of harmful and potentially harmful constituents (HPHCs) in the aerosol, and see if consumers would use the product

Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author

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The shift towards a pathogenic microbial profile often exacerbates inflammation, leading to tissue destruction and further compromising oral health [31, 32]